Journal article

A dose-specific meta-analysis of lipid changes in randomized controlled trials of atorvastatin and simvastatin

Sophie L Rogers, Dianna J Magliano, Dane B Levison, Kate Webb, Philippa J Clarke, Mendel P Grobler, Danny Liew

Clinical Therapeutics | ELSEVIER | Published : 2007


BACKGROUND: The available statins exhibit differences in the potency with which they alter serum lipid levels. OBJECTIVE: Meta-analyses were conducted to assess the relative potency of atorvastatin and simvastatin (the 2 most commonly prescribed statins) across all possible dose combinations in terms of changes in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C). METHODS: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, National Health Service (NHS) Centre for Reviews and Dissemination database, NHS Economic Evaluation Database, and Database of..

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