A dose-specific meta-analysis of lipid changes in randomized controlled trials of atorvastatin and simvastatin

Abstract

Background: The available statins exhibit differences in the potency with which they alter serum lipid levels. Objective: Meta-analyses were conducted to assess the relative potency of atorvastatin arid sinivastatin (the 2 most commonly prescribed statins) across all possible dose combinations in terrrrs of changes in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C). Methods: EDLINE, E BASE, the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, National Health Service (NHS) Centre for Reviews and Dissemination database, NHS Economic Evaluation Database, and Database..