A test of 1,25-dihydroxyvitamin D3 secretory capacity in normal subjects for application in metabolic bone diseases.
RL Prince, JD Wark, S Omond, JM Opie, MR Eagle, JA Eisman
Clin Endocrinol (Oxf) | Published : 1983
The circulating concentration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] varies in man in response to a variety of physiological stimuli. In pathological states, random plasma 1,25-(OH)2D3 levels reflect the sum of the underlying pathological process and the homeostatic corrections to those perturbations. Hence random 1,25-(OH)2D3 levels do not allow differentiation as to whether changes in 1,25-(OH)2D3 production or metabolism are primary or secondary to other changes. Similarly random levels do not provide much insight into the reserve of 1,25-(OH)2D3 secretory capacity. We have developed a single infusion of parathyroid extract (PTE) as a test of 1,25-(OH)2D3 secretory capacity. Normal re..View full abstract