Journal article
Genital Inflammation and the Risk of HIV Acquisition in Women
L Masson, JAS Passmore, LJ Liebenberg, L Werner, C Baxter, KB Arnold, C Williamson, F Little, LE Mansoor, V Naranbhai, DA Lauffenburger, K Ronacher, G Walzl, NJ Garrett, BL Williams, M Couto-Rodriguez, M Hornig, WI Lipkin, A Grobler, Q Abdool Karim Show all
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2015
DOI: 10.1093/cid/civ298
Abstract
Background. Women in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group. Methods. Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γinducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages fro..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The CAPRISA 004 parent trial was supported by USAID (http://www.usaid.gov), FHI 360 (http://www.fhi360.org; USAID cooperative agreement GPO-A-00-05-00022-00, contract 132119), and the Technology Innovation Agency (LIFElab) of the South African government's Department of Science & Technology (http://www.dst.gov.za). Tenofovir was provided by Gilead Sciences, and the gel was manufactured and supplied for the CAPRISA 004 trial by CONRAD (http://www.conrad.org). The current studies are part of the CAPRISA TRAPS Program, which is funded by CONRAD, Eastern Virginia Medical School (USAID cooperative grant GP00-08-00005-00, subproject agreement PPA-09-046), and the South African Department of Science & Technology. D. A. L. and K. B. A. were funded by the US National Institutes of Health (NIH; U19-AI0859). Cytokine Luminex assays were funded by a grant from the Poliomyelitis Research Foundation of South Africa (J.- A. S. P.); the South African Medical Research Council, the Carnegie Corporation, University of Cape Town Clinical Infectious Diseases Research Initiative (Wellcome Trust), and the National Research Foundation of South Africa [L. M.]. We thank the NIH's Comprehensive International Program of Research on AIDS (http://www.nih.gov; CIPRA grant AI51794) for the research infrastructure.