Journal article
Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome
CC Chang, AA Dorasamy, BI Gosnell, JH Elliott, T Spelman, S Omarjee, V Naranbhai, Y Coovadia, T Ndung'U, MYS Moosa, SR Lewin, MA French
AIDS | Published : 2013
Abstract
Objective: HIV-infected patients with treated cryptococcal meningitis are at risk for further neurological deterioration after commencing combination antiretroviral therapy (cART), mostly because of cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). Identifying predictors of C-IRIS could enable risk stratification. Design: Prospective, longitudinal cohort study for 24 weeks. Setting: Durban, South Africa. Participants: One hundred and thirty HIV-infected patients with first cryptococcal meningitis episode Intervention: Antifungal therapy (amphotericin 1 mg/kg median 14 days, followed by consolidation and maintenance fluconazole) and cART (commenced median of 18 d..
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Funding Acknowledgements
C.C.C. was supported by the Australian Commonwealth Government for the Australian Postgraduate Award 2009 and Australian NHMRC (National Health and Medical Research Council) Postgraduate Scholarship 2010-2012. T.N. was supported in part by an international Early Career Scientist grant from the Howard Hughes Medical Institute and by the South African Department of Science and Technology/National Research Foundation Research Chairs Initiative. S. R. L. is an NHMRC practitioner fellow. M.A.F. was supported by NHMRC grant 510448.The authors would like to acknowledge the patients and their families, the medical, nursing, laboratory and support staff at King Edward VIII Hospital, Durban and Department of Microbiology, Inkosi Albert Luthuli Central Hospital, Durban. This work was supported by REACH Initiative (Research and Education in HIV/AIDS for Resource Poor Countries).