Journal article

A prospective cohort study of pulmonary function during pregnancy in women with and without asthma

Elida Zairina, Michael J Abramson, Christine F McDonald, Peter Rochford, Gary Nolan, Kay Stewart, Eldho Paul, Susan P Walker, Johnson George

Journal of Asthma | TAYLOR & FRANCIS LTD | Published : 2016


BACKGROUND AND OBJECTIVE: Pregnancy alters the severity of asthma unpredictably. Uncertainty still exists about longitudinal changes in pulmonary function during pregnancy in both healthy and asthmatic women. This study aimed to compare pulmonary function changes during pregnancy in healthy and asthmatic women and to determine the relationship between pulmonary function and asthma-related quality of life during pregnancy. A secondary aim was to investigate the application of forced expiratory volume in 6 s (FEV6) for monitoring asthma during pregnancy. METHODS: Pregnant women with (n = 20) and without asthma (n = 20) had pulmonary function tests at 8-20, 21-28 and 29-40 weeks gestation. Thos..

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Funding Acknowledgements

Dr George has received in-kind support from Vitalograph, the manufacturers of COPD-6, for this research. Prof. Abramson and Dr George have held investigator-initiated research grants from Pfizer and Boehringer Ingelheim for unrelated research. Prof. Abramson has undertaken an unrelated consultancy for Astra Zeneca and received assistance with conference attendance from Boehringer-Ingelheim and Sanofi. Prof. McDonald has participated in advisory boards and educational meetings for Boehringer Ingelheim, Novartis, GSK and AstraZeneca.