Polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide APO sterilizes Acinetobacter baumannii-infected skin wounds in mice
Istvan Sebe, Eszter Ostorhazi, Aron Fekete, Krisztian N Kovacs, Romana Zelko, Ilona Kovalszky, Wenyi Li, John D Wade, Dora Szabo, Laszlo Otvos
Amino Acids | SPRINGER WIEN | Published : 2016
Native and designer cationic antimicrobial peptides are increasingly acknowledged as host defense molecules rather than true antimicrobials. Due to their ability to activate the innate immune system, these structures are used to treat uninfected and bacterially-infected wounds, including those harboring Acinetobacter baumannii. Previously we documented that when administered intramuscularly or topically in liquid formulations, the proline-rich host defense peptide dimer A3-APO accelerates uninfected wound re-epithelization and eliminates systemic and local A. baumannii, methicillin-resistant Staphylococcus aureus and other pathogen load from infected lesions better than conventional antibiot..View full abstract
Awarded by ARC Discovery Project
Part of the work reported was supported by an ARC Discovery Project Grant (DP150103522) to JDW who is also an NHMRC (Australia) Principal Research Fellow and Akhter Hossain. WL is the recipient of an MIRS PhD award. Research at the FINMH was also supported by the Victorian Government's Operational Infrastructure Support Program.