Journal article

TRIPRONUCLEAR HUMAN OOCYTES - ALTERED CLEAVAGE PATTERNS AND SUBSEQUENT KARYOTYPIC ANALYSIS OF EMBRYOS

I KOLA, A TROUNSON, G DAWSON, P ROGERS

BIOLOGY OF REPRODUCTION | SOC STUDY REPRODUCTION | Published : 1987

Abstract

Between 1 and 4% of human oocytes fertilized in vitro are tripronuclear. It has been reported that these tripronuclear oocytes can develop to grossly normal-appearing morulae and that chromosomally, these embryos could be triploid, diploid, or severely depleted. The etiology and proportion of apparently diploid and aneuploid embryos deriving from tripronuclear human oocytes is unknown. This study provides evidence for the first time that most (18 of 29) tripronuclear human oocytes cleave directly to 3-cells at the first cleavage division. These embryos have a severely abnormal (but not triploid) chromosomal complement. Furthermore, some (4 of 29) tripronuclear human oocytes cleave to 2-cells..

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