Epidemiological characteristics of women with high grade CIN who do and do not have human papillomavirus

Abstract

Objective Human papillomavirus infection is an important aetiological agent associated with the devel- opment of cervical neoplasia. However, even with the most sensitive methods of detection, human papillomavirus DNA has been detected in only 90% of cases of cervical cancer and between 80%-90% of cases of dysplasia. This study aimed to determine if there are epidemiological differences between women who are positive or negative for human papillomavirus. with high grade cervical intraepithelial neoplasia (CIN). Design Four hundred and sixty women with CIN 11 and 111 lesions were studied. To ensure optimal detection of human papillomavirus DNA, two specimens (i.e. tampon and cervical biopsy) ..