Journal article

Epidemiological characteristics of women with high grade CIN who do and do not have human papillomavirus

SN Tabrizi, CK Fairley, SJ Chen, AJ Borg, P Baghurst, MA Quinn, SM Garland

BJOG An International Journal of Obstetrics & Gynaecology | BLACKWELL SCIENCE LTD | Published : 1999

Abstract

OBJECTIVE: Human papillomavirus infection is an important aetiological agent associated with the development of cervical neoplasia. However, even with the most sensitive methods of detection, human papillomavirus DNA has been detected in only 90% of cases of cervical cancer and between 80%-90% of cases of dysplasia. This study aimed to determine if there are epidemiological differences between women who are positive or negative for human papillomavirus, with high grade cervical intraepithelial neoplasia (CIN). DESIGN: Four hundred and sixty women with CIN II and III lesions were studied. To ensure optimal detection of human papillomavirus DNA, two specimens (i.e. tampon and cervical biopsy) ..

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