Journal article

TNF-R1 as a first trimester marker for prediction of pre-eclampsia

Sammya Bezerra Maia e Holanda Moura, Felicity Park, Padma Murthi, Wellington P Martins, Stefan C Kane, Paul Williams, Jonathan Hyett, Fabricio da Silva Costa

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | TAYLOR & FRANCIS LTD | Published : 2016

Abstract

OBJECTIVE: To examine whether the maternal serum concentration of the soluble receptor-1 of tumor necrosis factor-α (TNF-R1) at 11-13 + 6 weeks of gestation is a predictor of development of pre-eclampsia (PE). METHODS: This is a nested case-control study in which the concentration of TNF-R1 at 11 + 0 to 13 + 6 weeks was measured in 426 pregnant women in the first trimester. TNF-R1 values were expressed as multiples of the median (MoM) adjusted for maternal factors. The distributions of log TNF-R1 MoM in the control group and hypertensive disorders (early-PE [ePE], late-PE [lPE] and gestational hypertension [GH]) groups were compared. Logistic regression analysis was used to determine whether..

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