Journal article

Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease

Chantal Donovan, Simon R Bailey, Jenny Tran, Gertruud Haitsma, Zaridatul A Ibrahim, Simon R Foster, Mimi LK Tang, Simon G Royce, Jane E Bourke

American Journal of Physiology-Lung Cellular and Molecular Physiology | AMER PHYSIOLOGICAL SOC | Published : 2015

DOI: 10.1152/ajplung.00156.2015

Related Projects (1)

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Targeting Small Airways To Overcome Resistance To Therapy In Asthma

There is a pressing need to overcome resistance to current therapies for severe asthma. Targetting inflammation-induced changes in small air..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by National Health and Medical Research Council Grants 509239 and 1041575.

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Keywords

Peroxisome Proliferator-Activated Receptor-Γ
Lung
Respiratory System
Kappa-B
Proliferation
Anti-Asthmatic Agents
Muscle Relaxation
Thiazolidinediones
Drug Evaluation, Preclinical
Mice, Inbred Balb C
Murine Model
Rosiglitazone
Smooth-Muscle Relaxation
Methacholine Chloride
Muscle, Smooth
Peroxisome Proliferator-Activated Receptor-Gamma
Ppar-Gamma
Asthma
Male
Bronchodilation
Agonist Rosiglitazone
Guinea-Pig Trachea
Allergic Airways Disease
Bronchodilator
Physiology
Trachea
Female
Lung Slice
Adrenergic Beta-Agonists
Activated-Receptor-Gamma
Animals
Guinea Pigs
Science & Technology
Life Sciences & Biomedicine