Challenging historical perspectives of the 24-h chemotherapy day: Flexible chemotherapy dose-timing guidelines

Abstract

Aim: Variation in dose-timing within multiday chemotherapy regimens is largely unknown with convention being to administer subsequent days of treatment at 24-h intervals. However, in reality there are many occasions where doses are given either earlier or later to accommodate a variety of clinical and operational priorities. This project aimed to evaluate the degree of existing variation in chemotherapy dose-timing and to investigate whether deliberate variation could improve quality and efficiency outcomes such as reduction of after hours chemotherapy administration or reduced inpatient length of stay. Method: Chemotherapy charts and hospital admission datasets (n=112) from sarcoma and hema..