Journal article

INVESTIGATION OF KARYOTYPIC, MORPHOLOGIC AND CLINICAL-FEATURES IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA BLAST CELLS EXPRESSING THE NEURAL CELL-ADHESION MOLECULE (CD56)

JF SEYMOUR, SA PIERCE, HM KANTARJIAN, MJ KEATING, EH ESTEY

LEUKEMIA | NATURE PUBLISHING GROUP | Published : 1994

Abstract

The mechanisms of extramedullary leukemic infiltration are not well characterized. The cell-surface glycoprotein CD56, which is identical to the neural cell adhesion molecule, may be involved. Using the Leu-19 antibody and flow cytometric methods, the leukemic blasts of 22% (70 of 314) of patients were CD56 positive. This was most common in acute monocytic leukemia (15 of 18, 83%) and in patients with the cytogenetic abnormalities t(8;21) (seven of 13, 54%) and trisomy 8 (nine of 22, 41%). CD56 expression was not associated with extramedullary leukemic infiltration, but was correlated with positivity for CD11b (p < 0.001), CD14 (p < 0.001) and CD19 (p = 0.018). Although associated with morph..

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