Detection of canine carriers of haemophilia A using factor VIII activity and von Willebrand factor antigen concentration

Abstract

The ability of logistic regression analysis to correctly discriminate between 18 normal German shepherd bitches and 16 German shepherd bitches heterozygous for haemophilia A was assessed. Four equations were calculated using factor VIII activity alone, von Willebrand factor antigen concentration alone, the ratio of these two variables, or the two variables together but not as a ratio. In all models, the misclassification rates were sufficiently high to limit the value of these methods. © 1993.