Journal article
A simple and versatile method for microencapsulation of anti-epileptic drugs for focal therapy of epilepsy
Y Chen, Z Yue, SE Moulton, P Hayes, MJ Cook, GG Wallace
Journal of Materials Chemistry B | ROYAL SOC CHEMISTRY | Published : 2015
DOI: 10.1039/c5tb00675a
Abstract
Nearly 30% of epilepsy cases cannot be adequately controlled with current medical treatments. The reasons for this are still not well understood, but there is a significant body of evidence pointing to the blood-brain barrier. Resective surgery can provide an alternative method of epilepsy control; however this treatment option is not suitable for most epilepsy sufferers. Local drug delivery through micro-injection to or implantation into the brain provides an innovative approach to bypass the blood-brain barrier for epilepsy treatment. In order to develop effective local delivery systems for anti-epilepsy drug (AED), we have prepared a variety of core-shell microcapsules via electrojetting,..
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Awarded by Australian Research Council Centre of Excellence Scheme
Awarded by ARC
Funding Acknowledgements
Funding from the Australian Research Council Centre of Excellence Scheme (Project Number CE 140100012) is gratefully acknowledged. GGW is grateful to the ARC for support under the Australian Laureate Fellowship scheme (FL110100196). The authors are grateful to UCB Pharma for continued support. The authors gratefully acknowledge Mr Tony Romeo and Mr Mitchell Nancarrow from Electron Microscope Centre (EMC) for technical assistance of SEM images statistical analysis. The authors also gratefully acknowledge the use of facilities within the Australian National Fabrication Facility (ANFF).