Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway
Yann Wan Yap, Roxana M Llanos, Sharon La Fontaine, Michael A Cater, Philip M Beart, Nam Sang Cheung
Neurochemical Research | SPRINGER/PLENUM PUBLISHERS | Published : 2016
Mitochondrial dysfunction, ubiquitin-proteasomal system impairment and excitotoxicity occur during the injury and death of neurons in neurodegenerative conditions. The aim of this work was to elucidate the cellular mechanisms that are universally altered by these conditions. Through overlapping expression profiles of rotenone-, lactacystin- and N-methyl-D-aspartate-treated cortical neurons, we have identified three affected biological processes that are commonly affected; oxidative stress, dysfunction of calcium signalling and inhibition of the autophagic-lysosomal pathway. These data provides many opportunities for therapeutic intervention in neurodegenerative conditions, where mitochondria..View full abstract
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Awarded by NHMRC Research Fellowship
PMB were supported a NHMRC Research Fellowship (APP1019833). The Florey Institute of Neuroscience and Mental Health receives infrastructure support from the Victorian State Government (Australia).