Neutrophils: important contributors to tumor progression and metastasis
Agnieszka Swierczak, Kellie A Mouchemore, John A Hamilton, Robin L Anderson
CANCER AND METASTASIS REVIEWS | SPRINGER | Published : 2015
The presence of neutrophils in tumors has traditionally been considered to be indicative of a failed immune response against cancers. However, there is now evidence showing that neutrophils can promote tumor growth, and increasingly, the data support an active role for neutrophils in tumor progression to distant metastasis. Neutrophils have been implicated in promoting metastasis in cancer patients, where neutrophil numbers and neutrophil-related factors and functions have been associated with progressive disease. Nevertheless, the role of neutrophils in tumors, both at the primary and secondary sites, remains controversial, with some studies reporting their anti-tumor functions. This review..View full abstract
Awarded by National Breast Cancer Foundation
The authors wish to acknowledge funding from the National Health and Medical Research Council (NHMRC) of Australia, research fellowships to JAH (NHMRC) and RLA (National Breast Cancer Foundation), and scholarship support to AS (NHMRC) and KAM (Monash University).