Journal article

Screening Flavonoids for Inhibition of Acetylcholinesterase Identified Baicalein as the Most Potent Inhibitor

Azize Balkis, Khoa Tran, Yan Zhi Lee, Ken Ng

Journal of Agricultural Science | Canadian Center of Science and Education

Abstract

Screening phenolic and polyphenolic compounds for inhibitory activity against electric eels acetylcholinesterase (AChE) identified baicalein, a major flavone derived from the roots of Scutellaria baicalensis, as the most potent inhibitor with IC50 (concentration required for 50% inhibition) of 0.61 μM. None of the hydroxybenzoic and hydroxycinnamic acids screened showed inhibitory activity measured at 100 μM. Structure-activity relationships based on IC50 values of the active flavonoids showed that inhibitory activity (a) required the unsaturated 2-phenyl-chroman structure, (b) has strong requirement for the A-ring A5-OH, A6-OH and A7-OH groups (b) does not depend on B-ring hydroxyl groups, ..

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University of Melbourne Researchers

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