Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: The RISC study

SR De Rooij; JM Dekker; M Kozakova; A Mitrakou; O Melander; R Gabriel; C Guidone; K Højlund; MS Murphy; G Nijpels; J Dekker; S De Rooij; G Nijpels; W Boorsma; S Tournis; K Kyriakopoulou; P Thomakos; N Lalic; K Lalic; A Jotic; L Lukic; M Civcic; J Nolan; TP Yeow; M Murphy; C DeLong; G Neary; MP Colgan; M Hatunic; T Konrad; H Böhles; S Fuellert; F Baer; H Zuchhold; A Golay; E Harsch Bobbioni; V Barthassat; V Makoundou; TNO Lehmann; T Merminod; JR Petrie; C Perry; F Neary; C MacDougall; K Shields; L Malcolm; M Laakso; U Salmenniemi; A Aura; R Raisanen; U Ruotsalainen; T Sistonen; M Laitinen; H Saloranta; SW Coppack; N McIntosh; J Ross; L Pettersson; P Khadobaksh; M Laville; F Bonnet; A Brac De La Perriere; C Louche-Pelissier; C Maitrepierre; J Peyrat; S Beltran; A Serusclat; ME Sánchez; R Carraro; A Friera; S Perez; P Nilsson; M Persson; G Östling; O Melander; P Burri; PM Piatti; LD Monti; E Setola; E Galluccio; F Minicucci; A Colleluori; M Walker; IM Ibrahim; M Jayapaul; D Carman; C Ryan; K Short; Y McGrady; D Richardson; H Beck-Nielsen; P Staehr; V Vestergaard; C Olsen; L Hansen; GB Bolli; F Porcellati; C Fanelli

Journal article

Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: The RISC study

SR De Rooij, JM Dekker, M Kozakova, A Mitrakou, O Melander, R Gabriel, C Guidone, K Højlund, MS Murphy, G Nijpels, J Dekker, S De Rooij, G Nijpels, W Boorsma, S Tournis, K Kyriakopoulou, P Thomakos, N Lalic, K Lalic, A Jotic Show all

European Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 2009

DOI: 10.1530/EJE-09-0058

Abstract

Objective: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30-60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was me..

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