Journal article

Fatty Liver Is Associated with Insulin Resistance, Risk of Coronary Heart Disease, and Early Atherosclerosis in a Large European Population

Amalia Gastaldelli, Michaela Kozakova, Kurt Hojlund, Allan Flyvbjerg, Angela Favuzzi, Asimina Mitrakou, Beverley Balkau



UNLABELLED: Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of..

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University of Melbourne Researchers


Awarded by European Union

Awarded by Italian National Research Council

Funding Acknowledgements

The RISC Study is partially supported by European Union Grant QLGI-CT-2001-01252. Additional support has been provided by AstraZeneca. (Sweden). The present work was partially supported also by grants from the Italian National Research Council ME.P05.016, the Danish Medical Research Council, the Danish Diabetes Association, the Italian Space Agency (ASI), Project on Disorders of Motor and Cardiorespiratory Control The European Group for the Study of Insulin Resistance is supported by Merck Sante', France.