Journal article

Insulin resistance, insulin response, and obesity as indicators of metabolic risk

Ele Ferrannini, Beverley Balkau, Simon W Coppack, Jacqueline M Dekker, Andrea Mari, John Nolan, Mark Walker, Andrea Natali, Henning Beck-Nielsen

The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2007

Abstract

CONTEXT: Insulin resistance (IR) and obesity, especially abdominal obesity, are regarded as central pathophysiological features of a cluster of cardiovascular risk factors (CVRFs), but their relative roles remain undefined. Moreover, the differential impact of IR viz. insulin response has not been evaluated. OBJECTIVE: The objective of this study was to dissect out the impact of obesity, abdominal obesity, and IR/insulin response on CVRF. DESIGN: This was a cross-sectional study. SETTING: The study was conducted at 21 research centers in Europe. SUBJECTS: The study included a cohort of 1308 nondiabetic subjects [718 women and 590 men, age 30-60 yr, body mass index (BMI) 17-44 kg.m(-2)]. MAIN..

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University of Melbourne Researchers