Insulin resistance, insulin response, and obesity as indicators of metabolic risk

E Ferrannini; B Balkau; SW Coppack; JM Dekker; A Mari; J Nolan; M Walker; A Natali; H Beck-Nielsen; RJ Heine; J Dekker; G Nijpels; W Boorsma; A Mitrakou; S Tournis; K Kyriakopoulou; P Thomakos; N Lalic; K Lalic; A Jotic; L Lukic; M Civcic; TP Yeow; M Murphy; C DeLong; G Neary; MP Colgan; M Hatunic; T Konrad; H Böhles; S Fuellert; F Baer; H Zuchhold; A Golay; E Harsch Bobbioni; V Barthassat; V Makoundou; TNO Lehmann; T Merminod; JR Petrie; C Perry; F Neary; C Mac-Dougall; K Shields; L Malcolm; M Laakso; U Salmenniemi; A Aura; R Raisanen; U Ruotsalainen; T Sistonen; M Laitinen; H Saloranta; N McIntosh; P Khadobaksh; M Laville; F Bonnet; AB De La Perriere; C Louche-Pelissier; C Maitrepierre; J Peyrat; A Serusclat; R Gabriel; EM Sánchez; R Carraro; A Friera; B Novella; P Nilsson; M Persson; G Östling; O Melander; P Burri; PM Piatti; LD Monti; E Setola; E Galluccio; F Minicucci; A Colleluori; IM Ibrahim; M Jayapaul; D Carman; K Short; Y McGrady; D Richardson; P Staehr; K Hojlund; V Vestergaard; C Olsen; L Hansen; GB Bolli; F Porcellati; C Fanelli; P Lucidi; F Calcinaro; A Saturni; E Muscelli; S Pinnola; M Kozakova; G Mingrone; C Guidone

Journal article

Insulin resistance, insulin response, and obesity as indicators of metabolic risk

E Ferrannini, B Balkau, SW Coppack, JM Dekker, A Mari, J Nolan, M Walker, A Natali, H Beck-Nielsen, RJ Heine, J Dekker, G Nijpels, W Boorsma, A Mitrakou, S Tournis, K Kyriakopoulou, P Thomakos, N Lalic, K Lalic, A Jotic Show all

Journal of Clinical Endocrinology and Metabolism | Published : 2007

DOI: 10.1210/jc.2007-0334

Abstract

Context: Insulin resistance (IR) and obesity, especially abdominal obesity, are regarded as central pathophysiological features of a cluster of cardiovascular risk factors (CVRFs), but their relative roles remain undefined. Moreover, the differential impact of IR viz. insulin response has not been evaluated. Objective: The objective of this study was to dissect out the impact of obesity, abdominal obesity, and IR/insulin response on CVRF. Design: This was a cross-sectional study. Setting: The study was conducted at 21 research centers in Europe. Subjects: The study included a cohort of 1308 nondiabetic subjects [718 womenand 590 men, age 30-60 yr, body mass index (BMI) 17-44 kg·m-2]. Main Ou..

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