The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

E Muscelli; M Kozàkovà; A Flyvbjerg; K Kyriakopoulou; BD Astiarraga; D Glintborg; T Konrad; A Favuzzi; JR Petrie; RJ Heine; J Dekker; S De Rooij; G Nijpels; W Boorsma; A Mitrakou; S Tournis; P Thomakos; N Lalic; K Lalic; A Jotic; L Lukic; M Civcic; J Nolan; TP Yeow; M Murphy; C DeLong; G Neary; MP Colgan; M Hatunic; H Böhles; S Fuellert; F Baer; H Zuchhold; A Golay; E Harsch Bobbioni; V Barthassat; V Makoundou; TNO Lehmann; T Merminod; C Perry; F Neary; C MacDougall; K Shields; L Malcolm; M Laakso; U Salmenniemi; A Aura; R Raisanen; U Ruotsalainen; T Sistonen; M Laitinen; H Saloranta; SW Coppack; N McIntosh; J Ross; L Pettersson; P Khadobaksh; M Laville; F Bonnet; A Brac De La Perriere; C Louche-Pelissier; C Maitrepierre; J Peyrat; S Beltran; A Serusclat; R Gabriel; EM Sánchez; R Carraro; A Friera; B Novella; P Nilsson; M Persson; G Östling; O Melander; P Burri; PM Piatti; LD Monti; E Setola; E Galluccio; F Minicucci; A Colleluori; M Walker; IM Ibrahim; M Jayapaul; D Carman; C Ryan; K Short; Y McGrady; D Richardson; H Beck-Nielsen; P Staehr; K Hojlund; V Vestergaard; C Olsen; L Hansen; GB Bolli; F Porcellati; C Fanelli

Journal article

The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

E Muscelli, M Kozàkovà, A Flyvbjerg, K Kyriakopoulou, BD Astiarraga, D Glintborg, T Konrad, A Favuzzi, JR Petrie, RJ Heine, J Dekker, S De Rooij, G Nijpels, W Boorsma, A Mitrakou, S Tournis, P Thomakos, N Lalic, K Lalic, A Jotic Show all

American Journal of Hypertension | OXFORD UNIV PRESS | Published : 2009

DOI: 10.1038/ajh.2009.16

Abstract

Background: The mechanisms by which menopause may influence the systemic subclinical atherosclerosis are unexplained. The aim of this cross-sectional study was to evaluate the associations between early menopause, established cardiovascular (c-v) risk factors, metabolic parameters (insulin secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. Methods: In 74 menopausal women (mean age = 51 ± 3 years, mean duration of menopause = 2.9 ± 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid artery (CCA) luminal diameter, and IMT in different carotid segments were measured in digitized ultrasound ..

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University of Melbourne Researchers

Sheila Patel Author

Grants

Awarded by European Commission

Funding Acknowledgements

The European Group for the Study of Insulin Resistance (EGIR) RISC study is partly supported by EU grant QLG1-CT-2001-01252. Additional support has been provided by AstraZeneca (Sweden). The EGIR is supported by Merck Sante, France. We thank Karen Mathiassen and Hanne Petersen for expert technical assistance.