G-CSF mobilised progenitor cells in autologous transplantation: in vitro and in vivo aspects.
CG Begley, E DeLuca, PA Rowlings, J Szer, D Watson, C Juttner, G Morstyn, RM Fox, W Sheridan
Journal of Nutritional Science and Vitaminology | Published : 1992
G-CSF administration leads to significant elevation in the levels of circulating progenitor cells. Infusion of these cells after high-dose chemotherapy is associated with accelerated platelet engraftment that has a considerable impact in shortening thrombocytopenia and reducing need for platelet transfusions.