Journal article

LONG-TERM SURVIVAL AFTER MARROW TRANSPLANTATION FOR PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA WITH APLASTIC-ANEMIA

J SZER, HJ DEEG, RP WITHERSPOON, A FEFER, CD BUCKNER, ED THOMAS, R STORB

ANNALS OF INTERNAL MEDICINE | AMER COLL PHYSICIANS | Published : 1984

Abstract

Four patients with paroxysmal nocturnal hemoglobinuria and severe marrow aplasia were given marrow grafts either from allogeneic human-leukocyte-antigen-identical siblings (three patients) or from a syngeneic donor (one patient). The patients with allogeneic grafts were conditioned with regimens that included cyclophosphamide and had sustained and complete marrow engraftment; subsequent tests were negative for paroxysmal nocturnal hemoglobinuria. One patient developed chronic graft-versus-host disease that resolved over 4 years. The patient receiving a syngeneic graft received marrow infusion without preceding immunosuppression. He had prompt engraftment, and hematologic variables returned t..

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