Journal article

Incidence and reasons for late failure after allogeneic haematopoietic cell transplantation following BuCy2 in acute myeloid leukaemia

Shubham Pant, Mehdi Hamadani, Anthony J Dodds, Jeffrey Szer, Pamela A Crilley, Dustin Stevenson, Gary Phillips, Patrick Elder, Ian Nivison-Smith, Belinda R Avalos, Sam Penza, David Topolsky, Ronald Sobecks, Matt Kalaycio, Brian J Bolwell, Edward A Copelan

BRITISH JOURNAL OF HAEMATOLOGY | WILEY | Published : 2010

Abstract

The long-term follow-up is presented for 317 patients with acute myeloid leukaemia who underwent human leucocyte antigen-identical sibling marrow transplants between 1984 and 1995 following preparation with busulfan 16 mg/kg and cyclophosphamide 120 mg/kg. Among the 142 (45%) who were alive and leukaemia-free 3 years following transplantation, the leukaemia-free survival at 15 years was 72.8%. The cumulative incidence of late (>3 years beyond transplant) non-relapse mortality at 15 years was 12.9% and of late relapse was 16.5%. None of the variables considered (including age, disease stage, and graft-versus-host disease) were predictive of late failure.