Journal article

Harmonizing FDG PET quantification while maintaining optimal lesion detection: prospective multicentre validation in 517 oncology patients

Elske Quak, Pierre-Yves Le Roux, Michael S Hofman, Philippe Robin, David Bourhis, Jason Callahan, David Binns, Cedric Desmonts, Pierre-Yves Salaun, Rodney J Hicks, Nicolas Aide

European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2015

Abstract

PURPOSE: Point-spread function (PSF) or PSF + time-of-flight (TOF) reconstruction may improve lesion detection in oncologic PET, but can alter quantitation resulting in variable standardized uptake values (SUVs) between different PET systems. This study aims to validate a proprietary software tool (EQ.PET) to harmonize SUVs across different PET systems independent of the reconstruction algorithm used. METHODS: NEMA NU2 phantom data were used to calculate the appropriate filter for each PSF or PSF+TOF reconstruction from three different PET systems, in order to obtain EANM compliant recovery coefficients. PET data from 517 oncology patients were reconstructed with a PSF or PSF+TOF reconstruct..

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