Journal article

Differential expression of type II, IV and cytosolic PLA(2) messenger RNA in human intrauterine tissues at term

KA Freed, EK Moses, SP Brennecke, GE Rice

Molecular Human Reproduction | OXFORD UNIV PRESS | Published : 1997


The involvement of phospholipase A2 (PLA2) enzymes in the formation of biologically-active phospholipid metabolites by human gestational tissues has principally been characterized by the use of enzyme activity assays. While such assays have established the presence of functional PLA2 activity, there is a paucity of information concerning the tissue distribution and relative contribution to net activity made by specific PLA2 isozymes. In particular, both secretory and cytosolic isozymes may be involved in gestational tissue phospholipid metabolism. Thus, the aim of this study was to test the hypothesis that phospholipase A2 mRNA transcripts encoding Type II, Type IV and cytosolic PLA2 are tis..

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