Journal article

Changes in myometrial expression of progesterone receptor membrane components 1 and 2 are associated with human parturition at term

Ray Wang, Penelope M Sheehan, Shaun P Brennecke

Reproduction Fertility and Development | CSIRO PUBLISHING | Published : 2016


While the exact mechanism of human parturition remains unknown, functional progesterone withdrawal is believed to play a key regulatory role. Progesterone receptor membrane components 1 and 2 (PGRMC1, PGRMC2) are putative progesterone receptors and the aim of this project was to investigate their expression in human myometrium. Human term myometrium was obtained from the lower uterine segment incision in women undergoing elective (not-in-labour, NIL; n=11) and emergency Caesarean sections (in-labour, IL; n=10), following written consent. PGRMC1 and 2 expression was quantified using real-time reverse transcription polymerase chain reaction and western blot. Subcellular localisation was perfor..

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Funding Acknowledgements

This work was supported, in part, by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists Research Foundation and the Collaborative Bachelor of Medical Science Scholarship to R. W. The authors thank Janet Stevenson and the Anatomical Pathology Department at the Royal Women's Hospital for valuable technical assistance.