Journal article

TUMOR-NECROSIS-FACTOR-ALPHA DURING HUMAN-PREGNANCY AND LABOR - MATERNAL PLASMA AND AMNIOTIC-FLUID CONCENTRATIONS AND RELEASE FROM INTRAUTERINE TISSUES

N LAHAM, SP BRENNECKE, K BENDTZEN, GE RICE

European Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 1994

Abstract

The aims of this study were: to quantify immunoreactive tumour necrosis factor alpha (TNF-alpha) concentrations in maternal plasma and amniotic fluid obtained from women during pregnancy and labour, both at term and preterm; and to establish the effects of bacterial endotoxin and cytokines on the in vitro release of TNF-alpha from intrauterine tissues. Maternal plasma TNF-alpha concentrations did not change during pregnancy (457.2 +/- 102.9 ng/l, mean +/- SEM, N = 52) or at the time of labour (543.5 +/- 138.6 ng/l, N = 43). In contrast, amniotic fluid TNF-alpha concentrations increased significantly (p < 0.05) during pregnancy (early pregnancy, EP, 93.0 +/- 24.8 ng/l, N = 7; preterm not-in-l..

View full abstract