Journal article

Angiotensinogen gene variation in a population case-control study of preeclampsia/eclampsia in Australians and Chinese

GL Guo, AN Wilton, YL Fu, HY Qiu, SP Brennecke, DW Cooper

Electrophoresis | VCH PUBLISHERS INC | Published : 1997


Preeclampsia/eclampsia (PE/E) is a common disease of human pregnancy with a strong genetic component. The etiology of PE/E is unknown. Two recent reports indicated that the angiotensinogen gene (AGT) could be involved in susceptibility to PE/E. We performed a population-based case-control study in Australian and Chinese populations to investigate whether AGT is a good candidate gene for PE/E. A microsatellite polymorphism within AGT was typed as well as a molecular variant T235 (Met-->Thr) of AGT using allele-specific PCR and allele-induced restriction site PCR. The allele distributions of the microsatellite and the variant T235 of AGT were significantly different between the two ethnic grou..

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