Journal article

CALCIUM DEPENDENCE OF ENDOGENOUS ACETYLCHOLINE-RELEASE INTO THE FETAL CIRCULATION OF THE DUALLY PERFUSED HUMAN PLACENTAL LOBULE

BR KRISHNA, RG KING, SP BRENNECKE

Journal of Perinatal Medicine | WALTER DE GRUYTER & CO | Published : 1992

Abstract

The aim of this study was to examine the role of calcium in the release of acetylcholine (ACh) from the fetal circulation of the dually perfused human placenta. The viability of this preparation was demonstrated; Glucose consumption and lactate production (as sums of both the fetal and maternal values) over the 4 h perfusion period were 13.9 +/- 4.2 mmol/kg/h (mean +/- SEM, n = 7) and 15.1 +/- 2.0 mmol/kg/h (n = 13) respectively. Mean pH levels of the fetal and maternal effluent perfusates were 7.26 +/- 0.02 (n = 5) and 7.32 +/- 0.01 (n = 5). None of these parameters varied significantly from 1 to 4 h of perfusion. ACh output into the fetal vessels after 1 h of perfusion was 0.31 +/- 0.02 nn..

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