Journal article

ABSENCE OF CLOSE LINKAGE BETWEEN MATERNAL GENES FOR SUSCEPTIBILITY TO PREECLAMPSIA ECLAMPSIA AND HLA DR-BETA

AN WILTON, DW COOPER, SP BRENNECKE, SM BISHOP, P MARSHALL

The Lancet | LANCET LTD | Published : 1990

Abstract

To test the possibility that maternally expressed susceptibility genes for pre-eclampsia/eclampsia are closely linked to the HLA region on chromosome 6 of the human genome, members of ten pedigrees with multiple cases of these disorders were typed for HLA DR beta restriction fragment length polymorphisms by means of TaqI digests. The data were analysed by the LIPED program to calculate lod scores, by several programs to detect potential heterogeneity of recombination fraction between pedigrees, and by the affected-sibling and the affected-pedigree-member methods. The results exclude close linkage. If the putative susceptibility genes lie on chromosome 6 they must lie at least 5 centiMorgans,..

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