Journal article

PLASMA-LEVELS OF ATRIAL NATRIURETIC PEPTIDES DURING PREGNANCY AND POST PARTUM IN THE RAT

C JANSAKUL, RG KING, ALA BOURA, SP BRENNECKE, GM HANDBERG

JOURNAL OF ENDOCRINOLOGY | J ENDOCRINOLOGY LTD | Published : 1989

Abstract

Plasma concentrations of atrial natriuretic peptides (ANP) in female Wistar rats were measured by radioimmunoassay at oestrus, during pregnancy, during parturition and between 3 h and 4 days post partum. Concentrations of ANP in rats on days 10, 15 and 17 of pregnancy were not significantly different from those in non-pregnant animals in oestrus (32.5 +/- 2.2 pmol/l; mean +/- S.E.M., n = 9), but levels near term (days 20 and 21 of pregnancy) were reduced by approximately 50%. However, plasma concentrations of ANP at 6, 12 and 24 h post partum were approximately twice those of non-pregnant animals in oestrus, but returned to normal levels within 4 days after parturition. Maternal plasma volum..

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