Journal article

HUMAN PLACENTAL ACETYLCHOLINE CONTENT AND RELEASE AT PARTURITION

SP BRENNECKE, S CHEN, RG KING, ALA BOURA

Clinical and Experimental Pharmacology and Physiology | WILEY | Published : 1988

Abstract

1. Measurements were made of human placental acetylcholine (ACh) content and release into maternal and fetal circulations from placenta obtained before, during and after labours of both spontaneous and induced onsets. ACh content was determined in ex vivo placental biopsies using a radio-enzymatic assay. ACh release was determined by bioassay of the effluent from placental lobules perfused with amniotic fluid-like Kreb's containing physostigmine (2.4 mumol/l). 2. ACh content of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) and during labour (spontaneous onset of labour, Caesarean section delivery) was significantly less than before labour (no labour o..

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