Journal article

HUMAN PLACENTAL CHOLINE-ACETYLTRANSFERASE ACTIVITY AT PARTURITION

YS CHEN, SP BRENNECKE, RG KING

PLACENTA | W B SAUNDERS CO LTD | Published : 1992

Abstract

Choline acetyltransferase (ChAT) activity measured in human placentae obtained during labour, or after labour of spontaneous onset, was significantly lower than that measured in placentae obtained before the onset of labour. The reduction in ChAT activity may partly account for the reduction in placental acetylcholine (ACh) content and release into maternal vessels at this time. When cycloheximide (10 micrograms/ml) was infused for 3 h into both fetal and maternal vessels of the perfused placental lobule, it did not significantly alter placental ChAT activity or ACh output from the fetal vessels, though it significantly reduced placental beta HCG release from the maternal side of the perfuse..

View full abstract