Journal article

ENDOTHELIN - RELEASE BY AND POTENT CONSTRICTOR EFFECT ON THE FETAL VESSELS OF HUMAN PERFUSED PLACENTAL LOBULES

NM GUDE, RG KING, SP BRENNECKE

Reproduction, Fertility and Development | CSIRO PUBLISHING | Published : 1991

Abstract

Human placental lobules were bilaterally perfused with a modified Krebs solution at constant flow rates of 5 mL min-1, and fetal inflow perfusion pressure was recorded. The effect of infusions of endothelin-1 and endothelin-3 (ET-1 and ET-3) on the perfusion pressure was assessed and compared with that for the thromboxane A2-mimetic U46619 and prostaglandin F2 alpha (PGF2 alpha). All substances caused significant increases in pressure, ET-1 being the most potent, followed in order by U46619, ET-3 and PGF2 alpha. In addition, ET-like immunoreactivity was identified in the fetal effluent of placental lobules during 4 h of basal perfusion. The mean ET-1 equivalent immunoreactivity at 1 h of per..

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