Journal article

MATERNAL PLASMA INHIBITION OF PROSTAGLANDIN SYNTHASE DURING HUMAN-PREGNANCY, PARTURITION AND THE PUERPERIUM

SP BRENNECKE, J HUMPHREYS, RL BRYCE, WP TEASDALE, AC TURNBULL, MD MITCHELL

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | BLACKWELL SCIENCE LTD | Published : 1984

Abstract

To study the possibility that circulating endogenous inhibitor(s) of prostaglandin synthesis (EIPS) represent a control mechanism for prostaglandin production during human pregnancy and parturition, we have measured maternal plasma EIPS levels serially during pregnancy, labour and the puerperium, and cross-sectionally during the course of labour. No significant trends were detected in relation to pregnancy or parturition. These results do not support a role for maternal plasma EIPS in the control of prostaglandin production during human pregnancy or labour.