Journal article

ONTOGENY AND NEONATOLOGY OF CIRCULATING ENDOGENOUS INHIBITOR(S) OF PROSTAGLANDIN SYNTHASE IN THE HUMAN

SP BRENNECKE, FJ KIRKHAM, KE MORTON, IZ MACKENZIE, AR WILKINSON, MD MITCHELL

Neonatology | KARGER | Published : 1984

Abstract

To further understand the mechanism by which in vivo prostaglandin synthesis may be orchestrated, plasma levels of endogenous inhibitor(s) of prostaglandin synthase (EIPS) in the human fetus, neonate and adult have been measured. In general, a reciprocal relationship was found between plasma EIPS levels and previously reported plasma prostaglandin concentrations. This result supports a role for EIPS in the control of prostaglandin biosynthesis in the human.