Journal article
Serrated tubulovillous adenoma of the large intestine
M Bettington, N Walker, C Rosty, I Brown, A Clouston, D Mckeone, SA Pearson, K Klein, B Leggett, V Whitehall
Histopathology | Published : 2016
DOI: 10.1111/his.12788
Abstract
Aims: Most colorectal polyps are classified readily, but a subset of tubulovillous adenomas (TVA) with prominent serrated architecture causes diagnostic confusion. We aimed to (i) identify histological features that separate serrated TVAs from both conventional TVAs and traditional serrated adenomas (TSA) and (ii) perform a clinicopathological and molecular analysis to determine if the serrated TVA has unique features. Methods and results: We collected 48 serrated TVAs, 50 conventional TVAs and 66 BRAF wild-type TSAs for analysis. For each polyp we performed a clinicopathological assessment, BRAF and KRAS mutation profiling, cytosine-phosphate-guanosine (CpG) island methylator phenotype stat..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We gratefully acknowledge NHMRC grant funding (ID: 1063105). M.B. gratefully acknowledges PhD scholarship funding from Cancer Council Queensland.