Journal article

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

J Fichna, DP Poole, N Veldhuis, SJ MacEachern, D Saur, PK Zakrzewski, AI Cygankiewicz, A Mokrowiecka, E Malecka-Panas, WM Krajewska, W Liedtke, MS Steinhoff, J-P Timmermans, NW Bunnett, KA Sharkey, MA Storr

Journal of Molecular Medicine | SPRINGER HEIDELBERG | Published : 2015

University of Melbourne Researchers


Awarded by Iuventus Plus program of the Polish Ministry of Science and Higher Education

Awarded by Medical University of Lodz

Awarded by National Science Centre

Awarded by NHMRC

Awarded by NIH

Awarded by Deutsche Forschungsgemeinschaft

Funding Acknowledgements

The authors wish to thank Dr. Kevin Thorneloe (GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA) for providing GSK1016790A for this study, Wolfgang Liedtke (Duke University, Durham, NC, USA) for providing the TRPV4<SUP>-/-</SUP> mice, and Drs. Catherine Legraverend (Institut de Genomique Fonctionnelle, Montpellier, France) and Richard Dyck (University of Calgary, AB, Canada) for supplying the S100 beta-GFP mice. SJM was supported by the Dr. T. Chen Fong Doctoral Scholarship in Neuroscience through the Hotchkiss Brain Institute and a Studentship from Alberta Innovates-Health Solutions (AI-HS). KAS is the Crohn's and Colitis Foundation of Canada Chair in IBD Research. Supported by the Iuventus Plus program of the Polish Ministry of Science and Higher Education (0107/IP1/2013/72 to JF), Medical University of Lodz (503/1-156-04/503-01 to JF), National Science Centre (UMO-2013/11/B/NZ7/01301 and UMO-2014/13/B/NZ4/01179 to JF), NHMRC (454858 to DPP and 63303 to NWB), NIH (DK57840 to NWB), Monash University (to NWB), the Canadian Institutes of Health Research (to KAS), the Deutsche Forschungsgemeinschaft (STO 645/6-1 to MS), and the University of Calgary Research Grant Committee (to MS).