Journal article

CD73: A potential biomarker for anti-PD-1 therapy

Paul A Beavis, Clare Y Slaney, Nicole Milenkovski, Melissa A Henderson, Sherene Loi, John Stagg, Michael H Kershaw, Phillip K Darcy

OncoImmunology | TAYLOR & FRANCIS INC | Published : 2015

Abstract

In our recent study, we show that tumoral CD73 expression limits the efficacy of anti-PD-1 therapy, and this is rescued by concomitant A2A blockade. Since CD73 is known to be overexpressed in several human cancers and A2A antagonists have undergone clinical trials for Parkinson's Disease, this combination warrants further investigation.