Journal article
The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium
NM Davies, TR Gaunt, SJ Lewis, J Holly, JL Donovan, FC Hamdy, JP Kemp, R Eeles, D Easton, Z Kote-Jarai, AA Al Olama, S Benlloch, K Muir, GG Giles, F Wiklund, H Gronberg, CA Haiman, J Schleutker, BG Nordestgaard, RC Travis Show all
Cancer Causes and Control | SPRINGER | Published : 2015
Abstract
Background: Epidemiological studies suggest a potential role for obesity and determinants of adult stature in prostate cancer risk and mortality, but the relationships described in the literature are complex. To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality. Methods: We conducted a case–control study based on 20,848 prostate cancers and 20,214 controls of European ancestry from 22 studies in the PRACTICAL consortium. We constructed genetic risk scores that summed each man’s number of height and BMI increasing alleles across multiple single nu..
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Awarded by Department of Health and Social Care
Funding Acknowledgements
Support for the analysis was provided by the World Cancer Research Fund (2011/419) and Cancer Research UK (C18281/A19169). The CRUK study and the PRACTICAL consortium were supported by the Canadian Institutes of Health Research; the European Commission's Seventh Framework Programme Grant agreement number 223175 (HEALTH-F2-2009-223175); Cancer Research UK Grants C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692, C16913/A6135; and the National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative Grant No. 1 U19 CA 148537-01 (the GAME-ON initiative). The ProtecT study is funded by the UK Health Technology Assessment (HTA) Programme of the NIH Research (HTA 96/20/99; ISRCTN20141297). The authors thank the provision of the additional epidemiological data by the NHS R&D Directorate supported Prodigal study and the ProMPT (Prostate Mechanisms of Progression and Treatment) collaboration which is supported by the National Cancer Research Institute (NCRI) formed by the Department of Health, the Medical Research Council and Cancer Research UK (G0500966/75466). RAE and ZKJ are supported by Cancer Research UK Grant C5047/A7357 and the NIHR Biomedical Research Centre at The Institute of Cancer Research and Royal Marsden NHS Foundation Trust. RMM was supported by the National Institute for Health Research Bristol Nutrition Biomedical Research Unit based at University Hospitals Bristol NHS Foundation Trust and the University of Bristol. FCH, DEN and JLD are NIHR Senior Investigators. The Integrative Epidemiology Unit is supported by the MRC and the University of Bristol (G0600705, MC_UU_12013/1,9). No funding body has influenced data collection, analysis, or its interpretations. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. This publication is the work of the authors, who serve as the guarantors for the contents of this paper.