Journal article

Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents

Mark Zeller, Elisabeth Heylen, Susan Damanka, Corinna Pietsch, Celeste Donato, Tsutomu Tamura, Ruta Kulkarni, Ritu Arora, Nigel Cunliffe, Leena Maunula, Christiaan Potgieter, Sana Tamim, Sarah De Coster, Elena Zhirakovskaya, Salwa Bdour, Helen O'Shea, Carl D Kirkwood, Mapaseka Seheri, Martin Monene Nyaga, Jeffrey Mphahlele Show all

Molecular Biology and Evolution | OXFORD UNIV PRESS | Published : 2015


The majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-)complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988-2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The..

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