Journal article
Emerging OP354-Like P[8] rotaviruses have rapidly dispersed from Asia to other continents
M Zeller, E Heylen, S Damanka, C Pietsch, C Donato, T Tamura, R Kulkarni, R Arora, N Cunliffe, L Maunula, C Potgieter, S Tamim, S De Coster, E Zhirakovskaya, S Bdour, H O'Shea, CD Kirkwood, M Seheri, MM Nyaga, J Mphahlele Show all
Molecular Biology and Evolution | Published : 2015
Abstract
The majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-)complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988-2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The..
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Funding Acknowledgements
M.Z. was supported by the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT Vlaanderen).