Journal article

The contribution of geometry to the human connectome

James A Roberts, Alistair Perry, Anton R Lord, Gloria Roberts, Philip B Mitchell, Robert E Smith, Fernando Calamante, Michael Breakspear



The human connectome is a topologically complex, spatially embedded network. While its topological properties have been richly characterized, the constraints imposed by its spatial embedding are poorly understood. By applying a novel resampling method to tractography data, we show that the brain's spatial embedding makes a major, but not definitive, contribution to the topology of the human connectome. We first identify where the brain's structural hubs would likely be located if geometry was the sole determinant of brain topology. Empirical networks show a widespread shift away from this geometric center toward more peripheral interconnected skeletons in each hemisphere, with discrete clust..

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Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (Program Grants 1037196 and 628952), the Australian Research Council (Centre of Excellence for Integrative Brain Function CE140100007 and Future Fellowship FT110100726), The Landsdowne Foundation, and the Victorian Government's Operational Infrastructure Support Grant.