Book Chapter

Role of the Alternate RAS in Liver Disease and the GI Tract

CB Herath, KY Mak, PW Angus

The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications | Published : 2015


Recent findings suggesting antifibrotic and vasodilatory functions of the alternate arm of the renin-angiotensin system (RAS) in liver disease open avenues for the development of drugs targeting the enzymes and/or receptors of this system. There is also new evidence showing that there is increased regional production of angiotensin-(1-7) (Ang-(1-7)) in the liver and mesenteric vascular bed in cirrhosis and that strategies such as long-term angiotensin-converting enzyme 2 (ACE2) therapy or oral formulations of Ang-(1-7) hold a promise for the treatment of patients with chronic liver disease. This arm of the RAS may also play an important protective role in the gastrointestinal tract and may b..

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