Fluorescent Nanodiamond Silk Fibroin Spheres: Advanced Nanoscale Bioimaging Tool
Asma Khalid, Alexander N Mitropoulos, Benedetto Marelli, David A Simpson, Phong A Tran, Fiorenzo G Omenetto, Snjezana Tomljenovic-Hanic
ACS Biomaterials Science and Engineering | AMER CHEMICAL SOC | Published : 2015
High resolution bioimaging is not only critical to the study of cellular structures and processes but it also has important applications in drug delivery and therapeutics. Fluorescent nanodiamonds (NDs) are excellent candidates for long-term bioimaging and tracking of biological structures at the nanoscale. Encapsulating NDs in natural biopolymers like silk fibroin (SF) widens their biomedical applications. Here we report the synthesis, structural and optical characterization of ND incorporated SF nanospheres. The photoluminescence from optical defects within the NDs is found to increase when encapsulated in the SF spheres. The encapsulated NDs are applied in vitro to investigate the intrace..View full abstract
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Awarded by ARC Australian Research Fellowship
A. Khalid is supported by Melbourne Research Scholarships awarded by The University of Melbourne and acknowledges Melbourne Scholarships for providing ORES funding to visit Prof. F.G. Omenetto at Tufts University. S. Tomljenovic-Hanic is supported by an ARC Australian Research Fellowship (DP1096288). The numerical part of research was undertaken with the assistance of resources provided at the NCI National Facility systems at The Australian National University through the National Computational Merit Allocation Scheme supported by the Australian Government.