Journal article

Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers

Stephanie Solso, Ronghui Xu, James Proudfoot, Donald J Hagler, Kathleen Campbell, Vijay Venkatraman, Cynthia Carter Barnes, Clelia Ahrens-Barbeau, Karen Pierce, Anders Dale, Lisa Eyler, Eric Courchesne

BIOLOGICAL PSYCHIATRY | ELSEVIER SCIENCE INC | Published : 2016

Abstract

BACKGROUND: Theories of brain abnormality in autism spectrum disorder (ASD) have focused on underconnectivity as an explanation for social, language, and behavioral deficits but are based mainly on studies of older autistic children and adults. METHODS: In 94 ASD and typical toddlers ages 1 to 4 years, we examined the microstructure (indexed by fractional anisotropy) and volume of axon pathways using in vivo diffusion tensor imaging of fronto-frontal, fronto-temporal, fronto-striatal, and fronto-amygdala axon pathways, as well as posterior contrast tracts. Differences between ASD and typical toddlers in the nature of the relationship of age to these measures were tested. RESULTS: Frontal tra..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Mental Health (NIMH)


Awarded by NIMH


Awarded by National Institutes of Health Clinical and Translational Science Award


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

This study was supported by National Institute of Mental Health (NIMH) Grant No. P50-MH081755 (to EC), NIMH Grant No. R01-MH36840 (to EC), NIMH Grant No. R01-MH080134 (to KP), and the National Foundation for Autism Research (to KP). Work by RX and JP was partially supported by the National Institutes of Health Clinical and Translational Science Award UL1TR000100 to University of California San Diego.