White Matter Hyperintensity Burden and Disability in Older Adults: Is Chronic Pain a Contributor?
Neilly Buckalew, Marc W Haut, Howard Aizenstein, Caterina Rosano, Kathryn Dunfee Edelman, Subashan Perera, Lisa Marrow, Stasa Tadic, Vijay Venkatraman, Debra Weiner
PM&R | ELSEVIER SCIENCE INC | Published : 2013
OBJECTIVE: To primarily explore differences in global and regional white matter hyperintensities (WMH) in older adults with self-reported disabling and nondisabling chronic low back pain (CLBP) and to examine the association of WMH with gait speed in all participants with CLBP. To secondarily compare WMH of the participants with CLBP with the pain-free controls. DESIGN: A cross-sectional, case-control study. SETTING: University of Pittsburgh. PARTICIPANTS: Twenty-four community-dwelling older adults: 8 with self-reported disabling CLBP, 8 with nondisabling CLBP, and 8 were pain-free. Exclusions were psychiatric or neurologic disorders (either central or peripheral), substance abuse, opioid u..View full abstract
Awarded by National Institute on Aging [NIA]
Awarded by NIA
Awarded by National Institute of Nursing Research
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
Awarded by NATIONAL INSTITUTE OF NURSING RESEARCH
Awarded by NATIONAL INSTITUTE ON AGING
We thank the HBP (funded under grant R01AG029232 by the National Institute on Aging [NIA]) and the Health ABC study (funded under N01-AG-6-2106, N01-AG-6-2103, and N01-AG-6-2106 by NIA contracts, as well as NIA grant R01-AG028050, and National Institute of Nursing Research grant R01-NR012459) for access to their data and their overall support with special thanks to Anne Newman, Tamara Harris, Gregory Hicks, Steve Kritchvsky, and Kristine Yaffe. We also thank the following people for their generous assistance and hard work in completing this study: Denise Davis at the University of Pittsburgh Medical Center, Presbyterian MR Research Center, and R. P. Detwiler. We thank Stephanie Studenski for sponsoring Neilly Buckalew under a National Institutes of Health T32 Predoc and Postdoc Training grant from the NIA and Amber Barnato of the Clinical Scientist Training Program and Michael Boninger of the Department of Physical Medicine and Rehabilitation for their added mentorship. We also extend our gratitude to the NIA for funding N. Buckalew's training as' well as to Arthur Levine, senior vice chancellor for the Health Sciences and dean of the School of Medicine at the University of Pittsburgh. This work was also supported by a grant from the University of Pittsburgh's Claude Pepper Older Americans Independence Center and in part by the Intramural Research Program of the National Institutes of Health, NIA.