Journal article

Aortic Pulse Wave Velocity Predicts Focal White Matter Hyperintensities in a Biracial Cohort of Older Adults

Caterina Rosano, Nora Watson, YueFang Chang, Anne B Newman, Howard J Aizenstein, Yan Du, Vijay Venkatraman, Tamara B Harris, Emma Barinas-Mitchell, Kim Sutton-Tyrrell

HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013

Abstract

Although the cross-sectional relationship of arterial stiffness with cerebral small vessel disease is consistently shown in middle-aged and young-old adults, it is less clear whether these associations remain significant over time in very old adults. We hypothesize that arterial stiffness is longitudinally associated with white matter characteristics, and associations are stronger within watershed areas. Neuroimaging was obtained in 2006-2008 from 303 elderly (mean age 82.9 years, 59% women, 41% black) with pulse wave velocity (PWV) measures in 1997-1998. Multivariable regression models estimated the coefficients for PWV (cm/sec) in relationship to presence, severity, and spatial distributio..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Institutes of Health's National Institute on Aging (NIA)


Awarded by NIA


Awarded by National Institute of Nursing Research


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NURSING RESEARCH


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This work was supported by National Institutes of Health's National Institute on Aging (NIA) contracts N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; NIA grant R01-AG028050; National Institute of Nursing Research grant R01-NR012459, R01 MH076079, P30 AG024827-06, R01 AG029232-01; and in part by the Intramural Research Program of the NIA.