Journal article
Multimodal imaging of the self-regulating developing brain
AM Fjell, KB Walhovd, TT Brown, JM Kuperman, Y Chung, DJ Hagler, V Venkatraman, J Cooper Roddey, M Erhart, C McCabe, N Akshoomoff, DG Amaral, CS Bloss, O Libiger, BF Darst, NJ Schork, BJ Casey, L Chang, TM Ernst, JR Gruen Show all
Proceedings of the National Academy of Sciences of the United States of America | Published : 2012
Abstract
Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4-21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component o..
View full abstractGrants
Awarded by National Institute on Drug Abuse
Funding Acknowledgements
The authors gratefully thank the children, adolescents, adults, and parents who participated in the research. Data collection and sharing for this project were funded by the PING Study (National Institutes of Health Grant RC2DA029475). PING is funded by the National Institute on Drug Abuse and the Eunice Kennedy Shriver National Institute of Child Health & Human Development. PING data are disseminated by the PING Coordinating Center at the Center for Human Development, University of California at San Diego. Additional support was received from the Norwegian Research Council (A.M.F. and K.B.W.), the European Research Council (A.M.F.), and National Institutes of Health Grant P41 EB015909.