Journal article

Patterns of Focal Gray Matter Atrophy Are Associated With Bradykinesia and Gait Disturbances in Older Adults

Caterina Rosano, David A Bennett, Anne B Newman, Vijay Venkatraman, Kristine Yaffe, Tamara Harris, Stephen Kritchevsky, Howard J Aizenstein

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | OXFORD UNIV PRESS INC | Published : 2012

Abstract

OBJECTIVES: Identify the neuroimaging correlates of parkinsonian signs in older adults living in the community. METHODS: Magnetic resonance imaging was obtained in 307 adults (82.9 years, 55% women, 39% blacks) concurrently with the Unified Parkinson Disease Rating scale-motor part. Magnetic resonance imaging measures included volume of whole-brain white matter hyperintensities and of gray matter for primary sensorimotor, supplementary motor, medial temporal areas, cerebellum, prefronto-parietal cortex, and basal ganglia. RESULTS: About 25% of the participants had bradykinesia, 26% had gait disturbances, and 12% had tremor. Compared with those without, adults with any one of these signs were..

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University of Melbourne Researchers

Grants

Awarded by National Institute on Aging (NIA)


Awarded by NIA


Awarded by National Institute of Nursing Research


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NURSING RESEARCH


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This research was supported by National Institute on Aging (NIA) contracts N01-AG-6-2101; N01-AG-6-2103, and N01-AG-6-2106; NIA grant R01-AG028050; National Institute of Nursing Research grant R01-NR012459, R01 MH076079, P30 AG024827-06 1, and R01 AG029232-01; and in part by the Intramural Research Program of the NIH, National Institute on Aging.